Description of primary multidrug-resistant tuberculous meningitis in an Italian child.
نویسندگان
چکیده
Tuberculous meningitis is the most severe form of tuberculosis and causes substantial morbidity and mortality in adults and children. The prevalence of multidrug-resistant (rifampin-isoniazid) strains requires the use of more toxic second-line drugs. We report a case of tuberculous meningitis in a 3-year-old Italian child.
منابع مشابه
Successful Treatment of a Child With Extensively Drug-Resistant Tuberculous Meningitis.
Unlike in pulmonary multidrug-resistant (MDR) tuberculosis, the clinical outcome of MDR tuberculous meningitis (TBM) in children, including extensively drug-resistant tuberculosis, is poor and management is challenging. We report the successful treatment of a case of extensively drug-resistant TBM in a 4-year-old girl, and we discuss implications for tuberculosis diagnosis and chemotherapy.
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Background: Patient immune status might be indicative of the variance in bacterial genetics in drug-resistant tuberculous pleuritis and could be used for predicting the risk of multi-drug resistant tuberculous pleuritis (MDR-TB). Objective: To determine the significance of Th2/Th1 ratio and concentration of PD-L1 in the pleural effusions for prediction of MDR-T...
متن کاملBeijing genotype of Mycobacterium tuberculosis is significantly associated with human immunodeficiency virus infection and multidrug resistance in cases of tuberculous meningitis.
Multidrug-resistant tuberculous meningitis is fatal without rapid diagnosis and use of second-line therapy. It is more common in human immunodeficiency virus (HIV)-positive patients. Beijing genotype strains of Mycobacterium tuberculosis are associated with drug resistance, particularly multidrug resistance, and their prevalence is increasing worldwide. The prevalence of Beijing genotype strain...
متن کاملClinical Outcomes of Patients With Drug-Resistant Tuberculous Meningitis Treated With an Intensified Antituberculosis Regimen
Background Drug-resistant tuberculous meningitis (TBM) is difficult to diagnose and treat. Mortality is high and optimal treatment is unknown. We compared clinical outcomes of drug-resistant and -susceptible TBM treated with either standard or intensified antituberculosis treatment. Methods We analyzed the influence of Mycobacterium tuberculosis drug resistance on the outcomes of patients wit...
متن کاملمقایسه غلظت آدنوزین‌دآمیناز مایع مغزی‌نخاعی در بیماران مننژیت سلی و غیر سلی
Background and Aim: Diagnosis of tuberculous meningitis is difficult because of its non-specific clinical presentations which may be confused with other disorders of central nervous system. The initiation of anti-TB medication can often be delayed because of lack of available laboratory tests. This study was aimed at evaluating the adenosine deaminase (ADA) concentration in differentiating tube...
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ورودعنوان ژورنال:
- Microbial drug resistance
دوره 18 1 شماره
صفحات -
تاریخ انتشار 2012